329-63-5

  • Product Name：Epinephrine Hydrochloride
  • Molecular Formula：C9H13NO3.HCl
  • Purity：99%
  • Molecular Weight：219.668
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Product Details

Melting Point:157℃

Appearance:solid

Purity:99%

Chinese Factory Supply Wholesale Epinephrine Hydrochloride 329-63-5 with Cheap Price

  • Molecular Formula:C9H13NO3.HCl
  • Molecular Weight:219.668
  • Appearance/Colour:solid 
  • Melting Point:157℃ 
  • Boiling Point:413.1 °C at 760 mmHg 
  • Flash Point:207.9 °C 
  • PSA：72.72000 
  • Density:1.283 g/cm3 
  • LogP:1.54350 

DL-ADRENALINE HYDROCHLORIDE(Cas 329-63-5) Usage

Biochem/physiol Actions

Epinephrine improves systemic pressure during cardiopulmonary resuscitation and is used post cardiac arrest. The levels of epinephrine increases during trauma, sepsis and hypoglycemia resulting in increased cardiac rate and contractility. It is used in the treatment of acute anaphylaxis. Use of epinephrine hydrochloride enables dilation of pupil during intraocular lens (IOL) implantation surgery.

General Description

Epinephrine is one of the most commonly used agents in various settings as it functions as medication and hormone. It is a mixed α/β-adrenergic receptor agonist and stimulates these receptors. Their site of synthesis is adrenal medulla and it travels through the vascular systems. Its breakdown occurs in the central nervous system (CNS), liver and kidney.
Uses Epinephrine Hydrochloride is used in emergencies to treat very serious allergic reactions to insect stings/bites, foods, drugs, or other substances. Epinephrine works quickly to improve breathing, stimulate the heart, raise a dropping blood pressure, reverse hives, and reduce swelling of the face, lips, and throat.

InChI:InChI=1/C9H13NO3.2ClH/c1-10-5-9(13)6-2-3-7(11)8(12)4-6;;/h2-4,9-13H,5H2,1H3;2*1H/p-1/t9-;;/m0../s1

329-63-5 Relevant articles

A new and efficient route for the synthesis of naturally occurring catecholamines

Bernini, Roberta,Crisante, Fernanda,Barontini, Maurizio,Fabrizi, Giancarlo

experimental part, p. 3838 - 3842 (2010/03/30)

Catecholamines, sympathomimetic drugs an...

Pharmacokinetics/pharmacodynamics of epinephrine after single and repeat administration of neffy, EpiPen, and manual intramuscular injection

Thomas B. Casale, MD Anne K. Ellis, MD Anna Nowak-Wegrzyn, MD, PhD Michael Kaliner, MD Richard Lowenthal, MS, MBA Sarina Tanimoto, MD, PhD

Anaphylaxis, drug allergy, urticaria, and angioedema| Volume 152, ISSUE 6, P1587-1596,

The pharmacokinetic profile of neffy was bracketed by approved injection products, with a mean peak plasma level of 481 pg/mL, which fell between EpiPen (753 pg/mL) and epinephrine manual intramuscular injection (339 pg/mL). When dosed both once and twice, neffy resulted in more pronounced increases in pharmacodynamic parameters relative to EpiPen or manual injection.

329-63-5 Process route

tert-butyl [2-(3,4-dihydroxyphenyl)-2-hydroxyethyl](methyl)carbamate
87697-27-6

tert-butyl [2-(3,4-dihydroxyphenyl)-2-hydroxyethyl](methyl)carbamate

epinephrine hydrochloride
329-63-5,66240-90-2

epinephrine hydrochloride

Conditions
Conditions Yield
With methanol; chloro-trimethyl-silane; for 3h; Reflux;
100%
epinephrine hydrochloride
329-63-5,66240-90-2

epinephrine hydrochloride

sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate
79060-88-1

sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate

C<sub>32</sub>H<sub>12</sub>BF<sub>24</sub><sup>(1-)</sup>*C<sub>9</sub>H<sub>13</sub>NO<sub>3</sub>*H<sup>(1+)</sup>

C32H12BF24(1-)*C9H13NO3*H(1+)

Conditions
Conditions Yield
In methanol; for 12h;
71%
In chloroform;
 

329-63-5 Upstream products

  • 87697-27-6
    87697-27-6

    tert-butyl [2-(3,4-dihydroxyphenyl)-2-hydroxyethyl](methyl)carbamate

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