150-83-4
- Product Name：Sodium 3-Hydroxybutyrate
- Molecular Formula：C4H8 O3 . Na
- Purity：99%
- Molecular Weight：126.088
Product Details
Melting Point:167-170 °C
Purity:99%
Perfect Factory Offer Excellent quality Sodium 3-Hydroxybutyrate 150-83-4 with Safe Shipping
- Molecular Formula:C4H8 O3 . Na
- Molecular Weight:126.088
- Vapor Pressure:0.000979mmHg at 25°C
- Melting Point:167-170 °C
- Boiling Point:269.2°Cat760mmHg
- Flash Point:121°C
- PSA：60.36000
- Density:g/cm3
- LogP:-1.49280
DL-3-HYDROXYBUTYRIC ACID SODIUM SALT(Cas 150-83-4) Usage
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Biological Functions |
Neuroprotective compound in experimental models of neurodegenerative diseases. Shown to be oxidized as an energetic substrate in the brain during starvation. May inhibit brain glucose oxidation, which may account for the suppression of hepatic glucose production observed after administration of ketone bodies in humans. |
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Biological Activity |
β-Hydroxybutyric acid is a ketone body present in the rumen epithelium of liver cells. Its interconversion to acetoacetate influences the acid-base balance and is coupled NADH generation from (nicotinamide adenine dinucleotide) NAD+, measured fluorimetrically. A high plasma level of β-hydroxybutyric acid is implicated in diabetic ketoacidosis. It traverses the blood-brain barrier as a monocarboxylic acid. β-Hydroxybutyric acid may play a protective role in dopaminergic neurodegeneration in Parkinson′s disease model. β-Hydroxybutyric acid is a ligand for G protein-coupled receptor(GPR109A) and favors inhibition of secretion, transcription and translation of growth hormone (GH) and prolactin (PRL) gene in cow anterior pituitary cells (DCAPCs). |
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Biochem/physiol Actions |
β-Hydroxybutyric acid is a ketone body present in the rumen epithelium of liver cells. Its interconversion to acetoacetate influences the acid-base balance and is coupled NADH generation from (nicotinamide adenine dinucleotide) NAD+, measured fluorimetrically. A high plasma level of β-hydroxybutyric acid is implicated in diabetic ketoacidosis. It traverses the blood-brain barrier as a monocarboxylic acid. β-Hydroxybutyric acid may play a protective role in dopaminergic neurodegeneration in Parkinson′s disease model. β-Hydroxybutyric acid is a ligand for G protein-coupled receptor(GPR109A) and favors inhibition of secretion, transcription and translation of growth hormone (GH) and prolactin (PRL) gene in cow anterior pituitary cells (DCAPCs). |
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Application |
DL-β-Hydroxybutyric acid sodium salt has been used:as a standard for quantifying blood plasma and milk β-hydroxybutyric acid in Danish Jersey cows.to investigate its anticonvulsant effects in epilepsy induced rats.to induce hyperketonemia in Holstein dairy cows. |
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Definition |
ChEBI: An organic sodium salt resulting from the replacement of the proton from the carboxy group of 3-hydroxybutyric acid by a sodium ion. |
InChI:InChI=1/C4H8O3.Na/c1-3(5)2-4(6)7;/h3,5H,2H2,1H3,(H,6,7);
150-83-4 Relevant articles
Catalyzed dehydrogenative coupling of primary alcohols with water, methanol, or amines
Zweifel, Theo,Naubron, Jean-Valere,Gruetzmacher, Hansjoerg
supporting information; experimental part, p. 559 - 563 (2009/04/14)
A working partnership: Metal-ligand coop...
150-83-4 Process route
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18826-95-4,107-88-0
1.3-butanediol
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150-83-4
sodium DL-3-hydroxybutyrate
| Conditions | Yield |
|---|---|
|
With
sodium hydroxide; Rh(trop2NH)(PPh3)(OTf); water; cyclohexanone;
at 25 ℃;
for 12h;
chemoselective reaction;
Inert atmosphere;
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67% |
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150-83-4
sodium DL-3-hydroxybutyrate
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300-85-6,625-71-8,26063-00-3,29435-48-1
3-Hydroxybutyric acid
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride;
In
water;
pH=2;
|
150-83-4 Upstream products
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18826-95-4
1.3-butanediol
150-83-4 Downstream products
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1135-39-3
benzyl 3-hydroxybutyrate
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300-85-6
3-Hydroxybutyric acid
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