What is the [(4-acetamidophenyl)(fluorosulfonyl)amino]sulfonyl fluoride?

[(4-acetamidophenyl)(fluorosulfonyl)amino]sulfonyl fluoride is , while it's Molecular Formula is C 8 H 8 F 2 N 2 O 5 S 2 . 4-(Acetylamino)phenyl]imidodisulfuryl difluoride (AISF) is a shelf-stable, crystalline reagent for synthesis of fluorosulfates and sulfamoyl fluorides via reaction with phenol and amine nucleophiles. A convenient alternative to the toxic sulfuryl fluoride gas traditionally required for installation of the valuable -SO2F functional group, the solid reagent AISF will find wide utility in preparation of synthetic precursors as well as chemical biology, polymer chemistry, cross-coupling, and deoxyfluorination applications. This product was introduced collaboratively with Pfizer and BioDuro.

What is the CAS number for [(4-acetamidophenyl)(fluorosulfonyl)amino]sulfonyl fluoride?

The CAS number of [(4-acetamidophenyl)(fluorosulfonyl)amino]sulfonyl fluoride is 2172794-56-6.

What is [(4-acetamidophenyl)(fluorosulfonyl)amino]sulfonyl fluoride (2172794-56-6) used for?

[(4-acetamidophenyl)(fluorosulfonyl)amino]sulfonyl fluoride, also known as 4-(Acetylamino)phenyl]imidodisulfuryl difluoride (AISF), is a shelf-stable, crystalline reagent derived from the collaboration between Pfizer and BioDuro. It is primarily used for the synthesis of fluorosulfates and sulfamoyl fluorides through its reaction with phenol and amine nucleophiles. AISF serves as a convenient and less toxic alternative to sulfuryl fluoride gas, which is traditionally used for the installation of the -SO2F functional group. Its solid-state nature and versatility make it a promising compound for various applications in chemical biology, polymer chemistry, cross-coupling, and deoxyfluorination.

What is the [(4-acetamidophenyl)(fluorosulfonyl)amino]sulfonyl fluoride?

[(4-acetamidophenyl)(fluorosulfonyl)amino]sulfonyl fluoride is , while it's Molecular Formula is C 8 H 8 F 2 N 2 O 5 S 2 . 4-(Acetylamino)phenyl]imidodisulfuryl difluoride (AISF) is a shelf-stable, crystalline reagent for synthesis of fluorosulfates and sulfamoyl fluorides via reaction with phenol and amine nucleophiles. A convenient alternative to the toxic sulfuryl fluoride gas traditionally required for installation of the valuable -SO2F functional group, the solid reagent AISF will find wide utility in preparation of synthetic precursors as well as chemical biology, polymer chemistry, cross-coupling, and deoxyfluorination applications. This product was introduced collaboratively with Pfizer and BioDuro.

What is the CAS number for [(4-acetamidophenyl)(fluorosulfonyl)amino]sulfonyl fluoride?

The CAS number of [(4-acetamidophenyl)(fluorosulfonyl)amino]sulfonyl fluoride is 2172794-56-6.

What is [(4-acetamidophenyl)(fluorosulfonyl)amino]sulfonyl fluoride (2172794-56-6) used for?

[(4-acetamidophenyl)(fluorosulfonyl)amino]sulfonyl fluoride, also known as 4-(Acetylamino)phenyl]imidodisulfuryl difluoride (AISF), is a shelf-stable, crystalline reagent derived from the collaboration between Pfizer and BioDuro. It is primarily used for the synthesis of fluorosulfates and sulfamoyl fluorides through its reaction with phenol and amine nucleophiles. AISF serves as a convenient and less toxic alternative to sulfuryl fluoride gas, which is traditionally used for the installation of the -SO2F functional group. Its solid-state nature and versatility make it a promising compound for various applications in chemical biology, polymer chemistry, cross-coupling, and deoxyfluorination.

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Product classification

2172794-56-6

Product Name：4-(ACETYLAMINO)PHENYL]IMIDODISULFURYL DIFLUORIDE
Molecular Formula：
Purity：99%
Molecular Weight：314.291

Inquiry

Product Details

Melting Point:146-149°C

Purity:99%

Manufacturer Supply Best Quality 4-(ACETYLAMINO)PHENYL]IMIDODISULFURYL DIFLUORIDE 2172794-56-6 with Efficient Transportation

Molecular Formula:C₈H₈F₂N₂O₅S₂
Molecular Weight:314.291
Melting Point:146-149°C
Density:1.741±0.06 g/cm3(Predicted)

2172794-56-6 Relevant articles

REAGENTS FOR FLUOROSULFATING ALCOHOLS OR AMINES

-

Paragraph 0084-0085, (2019/02/24)

Disclosed herein are compounds of formul...

SHP2 PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF

-

Paragraph 0230, (2019/10/15)

The present disclosure relates to novel ...

Introduction of a Crystalline, Shelf-Stable Reagent for the Synthesis of Sulfur(VI) Fluorides

Zhou, Hua,Mukherjee, Paramita,Liu, Rongqiang,Evrard, Edelweiss,Wang, Dianpeng,Humphrey, John M.,Butler, Todd W.,Hoth, Lise R.,Sperry, Jeffrey B.,Sakata, Sylvie K.,Helal, Christopher J.,Am Ende, Christopher W.

supporting information, p. 812 - 815 (2018/02/10)

The design, synthesis, and application o...

2172794-56-6 Process route

: 103-84-4
Acetanilid

: 2172794-56-6
[(4-acetamidophenyl)(fluorosulfonyl)amino]sulfonyl fluoride

Conditions

Conditions	Yield
With bis(fluorosulfonyl)imide lithium salt; [bis(acetoxy)iodo]benzene; In 1,2-dichloro-ethane; for 0.666667h; Time; Reflux;	86%
With bis(fluorosulfonyl)imide lithium salt; [bis(acetoxy)iodo]benzene; In 1,2-dichloro-ethane; for 0.666667h; Time; Reflux;	77%
With bis(fluorosulfonyl)imide lithium salt; [bis(acetoxy)iodo]benzene; In 1,2-dichloro-ethane; at 90 ℃; for 0.333333h; Inert atmosphere;	58%

2172794-56-6 Upstream products

103-84-4
Acetanilid

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